How to conduct advanced search for medical literature through PubMed?

PubMed advanced search enables precise retrieval of medical literature using structured query-building techniques and specialized tools beyond simple keyword searches. It is highly feasible through PubMed's dedicated interface and controlled vocabularies. Key principles involve utilizing controlled vocabulary (MeSH terms) alongside natural language keywords for comprehensive concept coverage. Boolean operators (AND, OR, NOT) combine or exclude concepts logically. Applying specific filters (e.g., publication date, article type, species, language) refines results significantly. Accessing these tools requires familiarity with PubMed’s "Advanced" search page options and the MeSH database. Effective searches depend on accurately defining the research question and translating it into appropriate search syntax. Implement this by first consulting the MeSH database to identify and select relevant descriptors for each core concept. Enter terms into the advanced search builder, combining them with Boolean operators to form the query’s logic. Next, apply essential filters like date range and article type directly within the search interface. Use field tags (e.g., [TIAB], [MAJR]) to restrict term searches to specific metadata fields. Finally, execute the search, review results, and iteratively refine the query based on relevance assessment and database indexing.