How to revise the submitted article during the journal submission process?

Revision of submitted manuscripts during the peer review process is generally feasible, but requires careful adherence to journal policy and procedure. Journal editors must grant explicit permission before any substantive changes are made. Revision requests typically fall into two categories: those initiated by the author to fix critical errors discovered *after* submission, or those prompted by reviewer/editor comments received during the evaluation. Permission must always be sought via the manuscript submission system; unsolicited file replacements are strongly discouraged. Journals usually permit corrections to minor errors (e.g., typographical mistakes) without formal permission if clearly highlighted. However, significant changes to methodology, data, findings, or conclusions require editorial approval to ensure fairness and integrity within the peer review. Crucially, all alterations, communication seeking permission, and replacement files must use the journal's designated online portal, not direct emails to editors. Always document requested changes concisely. To implement a revision, first formally request permission through the submission system, detailing the necessary changes and their critical nature. Upon receiving approval, promptly upload the revised manuscript file. Simultaneously, upload a detailed, point-by-point 'Response Letter' within the system. This letter must explicitly list all changes made, indicating their location within the manuscript (e.g., page, line number) and specifically addressing reviewer/editor feedback. Include any supplemental revised files (figures, tables). Strictly adhere to any deadlines provided by the journal to avoid withdrawal or delays. This structured approach maintains transparency and facilitates efficient editorial handling.